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A Phase II Study of Checkpoint Blockade Immunotherapy in Patients with Somatically Hypermutated Recurrent Glioblastoma (A071702)

Submitted by centretek on Sat, 10/15/2022 - 10:29
Read more about A Phase II Study of Checkpoint Blockade Immunotherapy in Patients with Somatically Hypermutated Recurrent Glioblastoma (A071702)
A Phase II Trial of Escalated Dose Proton Radiotherapy with Elective Nodal Irradiation and Concomitant Chemotherapy for Patients with Unresectable, Borderline Resectable or Medically Inoperable Pancreatic Adenocarcinoma (PCG PAN009-18)

Submitted by centretek on Sat, 10/15/2022 - 10:29
Read more about A Phase II Trial of Escalated Dose Proton Radiotherapy with Elective Nodal Irradiation and Concomitant Chemotherapy for Patients with Unresectable, Borderline Resectable or Medically Inoperable Pancreatic Adenocarcinoma (PCG PAN009-18)
A Phase II trial of SMO/AKT/NF2/CDK inhibitors in progressive meningiomas with SMO/AKT/NF2/CDK pathway mutations (A071401)

Submitted by centretek on Sat, 10/15/2022 - 10:29
Read more about A Phase II trial of SMO/AKT/NF2/CDK inhibitors in progressive meningiomas with SMO/AKT/NF2/CDK pathway mutations (A071401)
Phase III Randomized Trial of Proton Beam Therapy (PBT) versus Intensity Modulated Photon Radiotherapy (IMRT) for the Treatment of Esophageal Cancer (NRG-GI006)

Submitted by centretek on Sat, 10/15/2022 - 10:29
Read more about Phase III Randomized Trial of Proton Beam Therapy (PBT) versus Intensity Modulated Photon Radiotherapy (IMRT) for the Treatment of Esophageal Cancer (NRG-GI006)
A Phase III Trial of Perioperative Versus Adjuvant Chemotherapy for Resectable Pancreatic Cancer (A021806)

Submitted by centretek on Sat, 10/15/2022 - 10:29
Read more about A Phase III Trial of Perioperative Versus Adjuvant Chemotherapy for Resectable Pancreatic Cancer (A021806)
A Pilot Study of the Effect of Spironolactone Therapy on Exercise Capacity and Endothelial Dysfunction in Pulmonary Arterial Hypertension

Submitted by centretek on Sat, 10/15/2022 - 10:29
Read more about A Pilot Study of the Effect of Spironolactone Therapy on Exercise Capacity and Endothelial Dysfunction in Pulmonary Arterial Hypertension

Summary

A Pilot Study of the Effect of Spironolactone Therapy on Exercise Capacity and Endothelial Dysfunction in Pulmonary Arterial Hypertension
Pilot Study of Neoantigen Profiling in Patients with Melanoma Treated with PD-1 Blockade

Submitted by centretek on Sat, 10/15/2022 - 10:29
Read more about Pilot Study of Neoantigen Profiling in Patients with Melanoma Treated with PD-1 Blockade

Summary

This research study is designed to better understand the molecular determinants of response to immunotherapies including pembrolizumab and nivolumab. We hope to learn the relevance of tumor neoantigens in the recognition of cancer cells by the immune system. The ultimate goal is to rank and filter these neoantigens and correlate with response to immunotherapies.
Postoperative or Salvage Radiotherapy for Node Negative Prostate Cancer Following Radical Prostatectomy

Submitted by centretek on Sat, 10/15/2022 - 10:29
Read more about Postoperative or Salvage Radiotherapy for Node Negative Prostate Cancer Following Radical Prostatectomy
Pragmatic Phase III Randomized Trial Of Proton Vs. Photon Therapy For Patients With Non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (Radcomp) Consortium Trial (RTOG-3510)

Submitted by centretek on Sat, 10/15/2022 - 10:29
Read more about Pragmatic Phase III Randomized Trial Of Proton Vs. Photon Therapy For Patients With Non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (Radcomp) Consortium Trial (RTOG-3510)
Prognostic Gene Expression Profiling and Adjuvant Therapy in Stage IIIA-B Cutaneous Melanoma (PERSONALize)

Submitted by centretek on Sat, 10/15/2022 - 10:29
Read more about Prognostic Gene Expression Profiling and Adjuvant Therapy in Stage IIIA-B Cutaneous Melanoma (PERSONALize)