1. Examining the Microbiome Changes with Fecal Microbiota Transplantation (FMT) for Children with Recurrent Clostridium Difficile Infection

    Submitted by centretek on Sat, 10/15/2022 - 10:29
    Summary
    Clostridium difficile infection is an intestinal infection that can be life threatening. The incidence is increasing in children, and there is resistance to standard treatment with rising rates of recurrence. In resistant and recurrent cases, manipulation of the microbiome by FMT is an effective treatment. We are examining the intestinal microbiome in children before and after FMT to gain and better understanding of why this treatment is effective and also to improve FMT treatment in the future.
  2. Genome Research Alliance for Transplantation (GRAfT)

    Submitted by centretek on Sat, 10/15/2022 - 10:29
    Summary
    This study seeks to evaluate the relationship between donor-derived cell-free DNA and transplant rejection in heart and lung transplant patients. (Advanced Heart Failure group offers this study for heart transplant patients only.) This is a mid-Atlantic, multicenter prospective study to assess utility of donor-derived cell-free DNA as a marker of allograft rejection, cardiac allograft vasculopathy, CMV infection and other post-transplant complications.