There are two equally important primary hypotheses, which will be tested in two independent parallel, randomized clinical trials. One trial will test the primary hypothesis that intensive medical management differs from the combination of CEA and intensive medical management in preventing the primary endpoint in patients with high-grade asymptomatic carotid stenosis. One trial will test the primary hypothesis that intensive medical management differs from the combination of CAS and intensive medical management in preventing the primary endpoint in patients with high-grade asymptomatic carotid stenosis. In both trials, the primary endpoint is stroke or death within 44 days after randomization or ipsilateral ischemic stroke thereafter at the 4-year time point of follow-up.

A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens

C-TRACT is a large, well-designed study of new treatments for vein damage caused by blood clots. The goal of the study is to understand whether new image-guided procedures (endovascular therapy or EVT) reduce the severity of Post-Thrombotic Syndrome (PTS) and improve quality of life. The long-term safety and costs of the EVT procedure(s) will also be considered. Volunteers will be randomly assigned (like the flip of a coin) to either high quality PTS care (lifestyle interventions, compression therapy, and medical therapy) or high quality PTS care AND endovascular therapy (stent placement to re-open blocked veins and, if needed, endovenous ablation to eliminate backflow in veins with leaky valves). After randomization, patients will be asked to return to their clinical research center for study visits at 2 Months, 4 Months, 6 Months, 12 Months, 18 Months, and 24 Months.

A COG Soft Tissue Sarcoma Diagnosis, Biology and Banking Protocol

Collection and Storage of Blood/Biospecimens for Research in Patients Referred to the Inova Advanced Lung Disease Program

Have you, a friend, or family member been diagnosed with uterine fibroids? If so, you or they may qualify to join over 10,000 women participating in the COMPARE-UF Registry to understand better treatment options for women diagnosed with uterine fibroids. Inova is seeking women to participate in a research study to better understand treatment options for uterine fibroids. The national study is called Comparing Options for Management: Patient Centered Results for Uterine Fibroids, or COMPARE-UF. Inova is one of only nine sites in the country participating. The study is led by Duke University.