Observational Study Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs (EA2185)

General Information Age Group Adults ages 40 and older Status Recruiting Protocol Number NCT04239573 Background Information This study is being performed in collaboration with the Inova Saville Cancer Screening and Prevention Center. A pancreatic cyst is a small sac of fluid that grows on or inside of the pancreas. Pancreatic cysts come in different sizes and textures. A doctor will want to monitor and treat cysts based on how they look. This study is being done to determine if less frequent monitoring or more frequent monitoring will lead to better outcomes for patients with pancreatic cysts. Both methods use the same tests: either CT or MRI and endoscopic ultrasounds (also known as an EUS) where a machine uses sound waves to create images. The less frequent monitoring is based on guidelines created by the American Gastroenterological Association (AGA), while the more frequent monitoring is based on another set of guidelines known as the Fukuoka guidelines created from a group conference that agreed on the recommendations. The usual approach for patients who are not in a study is to use either CT or MRI imaging tests periodically according to the AGA and the Fukuoka guidelines. Both the AGA and the Fukuoka guidelines are used in practice today. Both methods use CT or MRI tests periodically. If there is a change in size, shape or other characteristics of a cyst, then patients often receive an EUS. Surgery is sometimes needed to determine whether the cysts are cancerous and to treat the cysts that progress to pancreatic cancer. This study has public funding from the National Cancer Institute (NCI), part of the National Institutes of Health (NIH) in the United States Department of Health and Human Services. Offered At Inova Schar Cancer Institute 8081 Innovation Park Dr. Fairfax, VA 22031 A department of Inova Fairfax Hospital Eligibility Information Between 50 and 75 years of age Have received a CT, MRI, or EUS within 6 months prior to randomization that revealed one or more ≥ 1 cm pancreatic cyst(s) Additional eligibility in protocol Ineligibility Information Pregnancy Prior diagnosis of pancreatic malignancy of any type Prior pancreatic resection Pancreatic lesions such as pancreatic pseudocyst or classic serous cystic lesion Acute pancreatitis or history of chronic pancreatitis Family history of pancreatic adenocarcinoma in one or more first-degree relatives (biological parents, full siblings or children) Additional ineligibility in protocol Additional information can be found at: https://clinicaltrials.gov/ct2/show/NCT04239573 Contact Information Contact Name Alexandra Greenbaum Contact Phone 571-472-0242 Contact Email Send Email